18-Hydroxycortisol

18-Hydroxycortisol is an endogenous steroid.[1][2][3][4]

18-Hydroxycortisol
Names
IUPAC name
(11β,17α)-11,17,18,21-Tetrahydroxypregn-4-ene-3,20-dione
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
UNII
Properties
C21H30O6
Molar mass 378.465 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Function

18-hydroxycortisol has been proposed as a biomarker for certain diseases. In humans, 18-hydroxycortisol has no biological activity on glucocorticoid or mineralocorticoid receptors. In healthy subjects, the biosynthesis of 18-hydroxycortisol is low. The highest synthesis of 18-hydroxycortisol was found in certain cases of hypertension like in type 1 familial hyperaldosteronism (glucocorticoid-curable hyperaldosteronism) and type 3 familial hyperaldosteronism, where the adrenal glands are enlarged up to six times their normal size. Increased synthesis is also found in patients with aldosterone-producing adenomas. ACTH stimulation test increases urinary excretion of 18-hydroxycortisol, and dexamethasone inhibits the excretion.[1]

See also

References
  1. Lenders J, Williams T, Reincke M, Gomez-Sanchez C (January 2018). "18-Oxocortisol and 18-hydroxycortisol: is there clinical utility of these steroids?". European Journal of Endocrinology. 178 (1): R1–R9. doi:10.1530/EJE-17-0563. PMC 5705277. PMID 28904009.
  2. Jin S, Wada N, Takahashi Y, Hui SP, Sakurai T, Fuda H, Takeda S, Fujikawa M, Yanagisawa K, Ikegawa S, Kurosawa T, Chiba H (September 2013). "Quantification of urinary 18-hydroxycortisol using LC-MS/MS". Annals of Clinical Biochemistry. 50 (Pt 5): 450–6. doi:10.1177/0004563213476272. PMID 23847032.
  3. Mulatero P, di Cella SM, Monticone S, Schiavone D, Manzo M, Mengozzi G, Rabbia F, Terzolo M, Gomez-Sanchez EP, Gomez-Sanchez CE, Veglio F (March 2012). "18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes". The Journal of Clinical Endocrinology and Metabolism. 97 (3): 881–9. doi:10.1210/jc.2011-2384. PMID 22238407.
  4. Chiba H (July 2010). "18-Hydroxycortisol, 18-oxocortisol, and 6beta-hydroxycortisol". Nihon Rinsho. Japanese Journal of Clinical Medicine (in Japanese). 68 Suppl 7: 339–43. PMID 20963880.
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