BIRC6

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.[5][6]

BIRC6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDsOMIM: 605638 MGI: 1276108 HomoloGene: 7248 GeneCards: BIRC6
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p22.3Start32,357,028 bp[1]
End32,618,899 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57448

12211

Ensembl

ENSG00000115760

ENSMUSG00000024073

UniProt

Q9NR09

O88738

RefSeq (mRNA)

NM_016252
NM_001378125

NM_007566

RefSeq (protein)

NP_057336
NP_001365054

NP_031592

Location (UCSC)Chr 2: 32.36 – 32.62 MbChr 17: 74.53 – 74.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[6]

Interactions

BIRC6 has been shown to interact with KIF23.[7]

Diseases

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers[8] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology[9]).

References

  1. GRCh38: Ensembl release 89: ENSG00000115760 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024073 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
  6. "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".
  7. Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369. S2CID 12192141.
  8. "BIRC6 (Baculoviral IAP repeat-containing 6)". atlasgeneticsoncology.org.
  9. "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.
  • Human BIRC6 genome location and BIRC6 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Baculoviral IAP repeat-containing protein 6

Further reading


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