UBE2C

UBE2C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I7K, 4YII, 5A31
Identifiers
Aliases	UBE2C, UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
External IDs	OMIM: 605574 MGI: 1915862 HomoloGene: 5096 GeneCards: UBE2C
EC number	2.3.2.24
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	45,816,957 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	164,778,822 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • ubiquitin-protein transferase activity; • GO:0001948 protein binding; • ATP binding; • ubiquitin conjugating enzyme activity; • ubiquitin protein ligase binding; • ubiquitin-like protein ligase binding;
Cellular component	• cytoplasm; • nucleoplasm; • anaphase-promoting complex; • cytosol; • cell membrane; • ubiquitin ligase complex; • cell nucleus;
Biological process	• free ubiquitin chain polymerization; • ubiquitin-dependent protein catabolic process; • exit from mitosis; • positive regulation of exit from mitosis; • protein K11-linked ubiquitination; • cell division; • protein K48-linked ubiquitination; • regulation of mitotic metaphase/anaphase transition; • cell cycle; • anaphase-promoting complex-dependent catabolic process; • GO:0090623, GO:1903835, GO:0007092, GO:0051488 positive regulation of ubiquitin protein ligase activity; • protein ubiquitination; • regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	11065
	68612
	ENSG00000175063
	ENSMUSG00000001403
	O00762; Q5TZN3
	Q9D1C1
NM_001281741; NM_001281742; NM_007019; NM_181799; NM_181800;
	NM_181801; NM_181802; NM_181803
	NM_026785
NP_001268670; NP_001268671; NP_008950; NP_861515; NP_861516;
	NP_861517; NP_008950.1
	NP_081061
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[6]

References

GRCh38: Ensembl release 89: ENSG00000175063 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000001403 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A. 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200.
"Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Tang Z, Li B, Bharadwaj R, et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Lin Y, Hwang WC, Basavappa R (2002). "Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10". J. Biol. Chem. 277 (24): 21913–21. doi:10.1074/jbc.M109398200. PMID 11927573.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Okamoto Y, Ozaki T, Miyazaki K, et al. (2003). "UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme". Cancer Res. 63 (14): 4167–73. PMID 12874022.
Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. S2CID 39773935.
Wagner KW, Sapinoso LM, El-Rifai W, et al. (2004). "Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin". Oncogene. 23 (39): 6621–9. doi:10.1038/sj.onc.1207861. PMID 15208666.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
Pallante P, Berlingieri MT, Troncone G, et al. (2005). "UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas". Br. J. Cancer. 93 (4): 464–71. doi:10.1038/sj.bjc.6602721. PMC 2361574. PMID 16106252.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Takahashi Y, Ishii Y, Nishida Y, et al. (2006). "Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH". Cancer Genet. Cytogenet. 168 (1): 30–5. doi:10.1016/j.cancergencyto.2005.12.011. PMID 16772118.
Lin J, Raoof DA, Wang Z, et al. (2007). "Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma". Neoplasia. 8 (12): 1062–71. doi:10.1593/neo.05832. PMC 1783715. PMID 17217624.
Ieta K, Ojima E, Tanaka F, et al. (2007). "Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression". Int. J. Cancer. 121 (1): 33–8. doi:10.1002/ijc.22605. PMID 17354233. S2CID 12277353.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175063 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001403 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9122200-5] Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A. 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200.

[entrez-6] "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

UBE2C

References

Further reading