CDC34

CDC34
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OB4, 3RZ3, 4MDK
Identifiers
Aliases	CDC34, E2-UBC3, UBCH3, UBE2R1, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme
External IDs	OMIM: 116948 MGI: 102657 HomoloGene: 55815 GeneCards: CDC34
EC number	2.3.2.24
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	542,092 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	79,688,398 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • ubiquitin-protein transferase activity; • GO:0001948 protein binding; • ATP binding; • ubiquitin conjugating enzyme activity; • ubiquitin protein ligase binding;
Cellular component	• cell nucleus; • nucleoplasm; • cytoplasm; • cytosol; • nuclear speck;
Biological process	• negative regulation of cAMP-mediated signaling; • cellular response to interferon-beta; • protein polyubiquitination; • positive regulation of inclusion body assembly; • protein K48-linked ubiquitination; • positive regulation of neuron apoptotic process; • cellular protein modification process; • DNA replication initiation; • cell cycle; • response to growth factor; • proteasome-mediated ubiquitin-dependent protein catabolic process; • protein ubiquitination; • G1/S transition of mitotic cell cycle; • ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	997
	216150
	ENSG00000099804
	ENSMUSG00000020307
	P49427
	Q8CFI2
	NM_004359
	NM_177613; NM_001359817; NM_001359818
	NP_004350
	NP_808281; NP_001346746; NP_001346747
	Wikidata
View/Edit Human	View/Edit Mouse

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1.[5][6][7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.[8]

CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle.[9] Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1[10] - for ubiquitin-mediated protein degradation.[11] CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[7]

Interactions

CDC34 has been shown to interact with CSNK2B,[12] BTRC[13][14] and CDK9.[15]

References

GRCh38: Ensembl release 89: ENSG00000099804 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020307 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Plon SE, Leppig KA, Do HN, Groudine M (November 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.
Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, et al. (October 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.
"Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".
Goebl MG, Yochem J, Jentsch S, McGrath JP, Varshavsky A, Byers B (September 1988). "The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme". Science. 241 (4871): 1331–5. doi:10.1126/science.2842867. PMID 2842867.
Dutcher SK, Hartwell LH (February 1982). "The role of S. cerevisiae cell division cycle genes in nuclear fusion". Genetics. 100 (2): 175–84. PMID 7049831.
King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. doi:10.1126/science.274.5293.1652. PMID 8939846.
Williams KM, Qie S, Atkison JH, Salazar-Arango S, Alan Diehl J, Olsen SK (July 2019). "Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34". Nature Communications. 10 (1): 3296. doi:10.1038/s41467-019-11061-8. PMID 31341161.
Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.
Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.

External links

Human CDC34 genome location and CDC34 gene details page in the UCSC Genome Browser.

King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. Bibcode:1996Sci...274.1652K. doi:10.1126/science.274.5293.1652. PMID 8939846. S2CID 25369228.
Pagano M (November 1997). "Cell cycle regulation by the ubiquitin pathway". FASEB Journal. 11 (13): 1067–75. doi:10.1096/fasebj.11.13.9367342. PMID 9367342. S2CID 6368478.
Lisztwan J, Marti A, Sutterlüty H, Gstaiger M, Wirbelauer C, Krek W (January 1998). "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway". The EMBO Journal. 17 (2): 368–83. doi:10.1093/emboj/17.2.368. PMC 1170388. PMID 9430629.
Song A, Wang Q, Goebl MG, Harrington MA (September 1998). "Phosphorylation of nuclear MyoD is required for its rapid degradation". Molecular and Cellular Biology. 18 (9): 4994–9. doi:10.1128/mcb.18.9.4994. PMC 109084. PMID 9710583.
Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, et al. (May 1999). "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha". The Journal of Biological Chemistry. 274 (21): 14823–30. doi:10.1074/jbc.274.21.14823. PMID 10329681.
Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Molecular and Cellular Biology. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
Seol JH, Feldman RM, Zachariae W, Shevchenko A, Correll CC, Lyapina S, et al. (June 1999). "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34". Genes & Development. 13 (12): 1614–26. doi:10.1101/gad.13.12.1614. PMC 316801. PMID 10385629.
Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, et al. (April 2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha". Molecular and Cellular Biology. 20 (7): 2326–33. doi:10.1128/MCB.20.7.2326-2333.2000. PMC 85397. PMID 10713156.
Reymond F, Wirbelauer C, Krek W (May 2000). "Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase". Journal of Cell Science. 113 ( Pt 10) (10): 1687–94. PMID 10769200.
Charrasse S, Carena I, Brondani V, Klempnauer KH, Ferrari S (June 2000). "Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway". Oncogene. 19 (26): 2986–95. doi:10.1038/sj.onc.1203618. PMID 10871850.
Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, et al. (July 2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4". Oncogene. 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.
Duan W, Sun B, Li TW, Tan BJ, Lee MK, Teo TS (October 2000). "Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo". Gene. 256 (1–2): 113–21. doi:10.1016/S0378-1119(00)00365-6. PMID 11054541.
Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
Wu K, Chen A, Tan P, Pan ZQ (January 2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34". The Journal of Biological Chemistry. 277 (1): 516–27. doi:10.1074/jbc.M108008200. PMID 11675391.
Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099804 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020307 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8248134-5] Plon SE, Leppig KA, Do HN, Groudine M (November 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.

[pmid16210246-6] Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, et al. (October 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.

[entrez-7] "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".

[goebl_1998-8] Goebl MG, Yochem J, Jentsch S, McGrath JP, Varshavsky A, Byers B (September 1988). "The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme". Science. 241 (4871): 1331–5. doi:10.1126/science.2842867. PMID 2842867.

[dutcher_1982-9] Dutcher SK, Hartwell LH (February 1982). "The role of S. cerevisiae cell division cycle genes in nuclear fusion". Genetics. 100 (2): 175–84. PMID 7049831.

[king_1996-10] King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. doi:10.1126/science.274.5293.1652. PMID 8939846.

[williams_2019-11] Williams KM, Qie S, Atkison JH, Salazar-Arango S, Alan Diehl J, Olsen SK (July 2019). "Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34". Nature Communications. 10 (1): 3296. doi:10.1038/s41467-019-11061-8. PMID 31341161.

[pmid11546811-12] Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.

[pmid12037680-13] Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.

[pmid10531035-14] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

[pmid11689688-15] Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.

CDC34

Interactions

References

External links

Further reading