CLIC1

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.[4][5]

CLIC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1
External IDsOMIM: 602872 MGI: 2148924 HomoloGene: 20343 GeneCards: CLIC1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.33Start31,730,581 bp[1]
End31,739,763 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1192

114584

Ensembl

ENSMUSG00000007041

UniProt

O00299

Q9Z1Q5

RefSeq (mRNA)

NM_001288
NM_001287593
NM_001287594

NM_033444

RefSeq (protein)

NP_001274522
NP_001274523
NP_001279

NP_254279

Location (UCSC)Chr 6: 31.73 – 31.74 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[5]

Interactions

CLIC1 has been shown to interact with TRAPPC2.[6]

See also

References

  1. ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 GRCh38: Ensembl release 89: ENSG00000213719, ENSG00000223639, ENSG00000226248, ENSG00000226651, ENSG00000226417, ENSG00000230685, ENSG00000206394 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J Biol Chem. 272 (19): 12575–82. doi:10.1074/jbc.272.19.12575. PMID 9139710.
  5. "Entrez Gene: CLIC1 chloride intracellular channel 1".
  6. Fan, Libin; Yu Wei; Zhu Xueliang (Apr 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. Netherlands. 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. ISSN 0014-5793. PMID 12681486. S2CID 8573651.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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