KCNIP1

Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.[5][6]

KCNIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCNIP1, KCHIP1, VABP, potassium voltage-gated channel interacting protein 1
External IDsOMIM: 604660 MGI: 1917607 HomoloGene: 22824 GeneCards: KCNIP1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q35.1Start170,353,487 bp[1]
End170,736,632 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

30820

70357

Ensembl

ENSG00000182132

ENSMUSG00000053519

UniProt

Q9NZI2

Q9JJ57

RefSeq (mRNA)

NM_001034837
NM_001034838
NM_001278339
NM_001278340
NM_014592

NM_001190885
NM_001190886
NM_001290690
NM_027398
NM_001363115

RefSeq (protein)

NP_001030009
NP_001030010
NP_001265268
NP_001265269
NP_055407

NP_001177814
NP_001177815
NP_001277619
NP_081674
NP_001350044

Location (UCSC)Chr 5: 170.35 – 170.74 MbChr 11: 33.63 – 33.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000182132 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053519 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID 10676964. S2CID 4419472.
  6. "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
  7. Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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