MCOLN2

MCOLN2
Identifiers
Aliases	MCOLN2, TRP-ML2, TRPML2, mucolipin 2
External IDs	OMIM: 607399 MGI: 1915529 HomoloGene: 12258 GeneCards: MCOLN2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	84,997,113 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	146,195,513 bp[2]
Gene ontology
Molecular function	• calcium channel activity; • cation channel activity; • NAADP-sensitive calcium-release channel activity;
Cellular component	• integral component of membrane; • membrane; • lysosome; • lysosomal membrane; • endosome; • cell membrane; • late endosome membrane; • recycling endosome membrane; • recycling endosome;
Biological process	• ion transport; • adaptive immune response; • immune system process; • calcium ion transport; • protein transport; • innate immune system; • calcium ion transmembrane transport; • positive regulation of chemokine production; • protein oligomerization; • positive regulation of monocyte chemotactic protein-1 production; • positive regulation of macrophage inflammatory protein 1 alpha production; • positive regulation of chemokine (C-C motif) ligand 5 production; • macrophage migration; • neutrophil migration; • positive regulation of chemokine (C-X-C motif) ligand 2 production; • release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	255231
	68279
	ENSG00000153898
	ENSMUSG00000011008
	Q8IZK6
	Q8K595
	NM_153259; NM_001330647
	NM_001005846; NM_026656
	NP_001317576; NP_694991
	NP_001005846; NP_080932
	Wikidata
View/Edit Human	View/Edit Mouse

Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene.[5] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.[6]

References

GRCh38: Ensembl release 89: ENSG00000153898 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000011008 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs" (PDF). Traffic. 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026.

External links

MCOLN2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153898 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000011008 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382100-5] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

[pmid17662026-6] Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs" (PDF). Traffic. 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026.

MCOLN2

See also

References

External links