KCNJ4

Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or Kir2.3, is a human gene.[5]

KCNJ4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCNJ4, HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3, potassium voltage-gated channel subfamily J member 4, potassium inwardly rectifying channel subfamily J member 4
External IDsOMIM: 600504 MGI: 104743 HomoloGene: 3653 GeneCards: KCNJ4
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.1Start38,426,327 bp[1]
End38,455,199 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3761

16520

Ensembl

ENSG00000168135

ENSMUSG00000044216

UniProt

P48050

P52189

RefSeq (mRNA)

NM_152868
NM_004981

NM_008427

RefSeq (protein)

NP_004972
NP_690607

n/a

Location (UCSC)Chr 22: 38.43 – 38.46 MbChr 15: 79.48 – 79.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.[5]

Interactions

KCNJ4 has been shown to interact with:

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000168135 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044216 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4".
  6. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
  7. Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  8. Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (March 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". J. Cell Sci. 114 (Pt 5): 987–98. PMID 11181181.
  9. Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A (January 2000). "Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family". J. Neurosci. 20 (1): 156–62. doi:10.1523/JNEUROSCI.20-01-00156.2000. PMC 6774109. PMID 10627592.
  10. Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y (June 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. 282 (6): C1396–403. doi:10.1152/ajpcell.00615.2001. PMID 11997254.
  11. Olsen O, Liu H, Wade JB, Merot J, Welling PA (January 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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