TRPM3

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.[5]

TRPM3
Identifiers
AliasesTRPM3, GON-2, LTRPC3, MLSN2, transient receptor potential cation channel subfamily M member 3
External IDsOMIM: 608961 MGI: 2443101 HomoloGene: 62287 GeneCards: TRPM3
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.12-q21.13Start70,529,063 bp[1]
End71,446,904 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80036

226025

Ensembl

ENSG00000083067

ENSMUSG00000052387

UniProt

Q9HCF6

n/a

RefSeq (mRNA)
RefSeq (protein)

n/a

Location (UCSC)Chr 9: 70.53 – 71.45 MbChr 19: 22.14 – 23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.[6] TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.[7]

TRPM3 Ligands

Channel Blockers
  1. Mefenamic acid[8]
  2. Citrus fruit flavonoids, e.g. naringenin, isosakuranetin and hesperetin, as well as ononetin (a deoxybenzoin).[9]

Agonist

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000083067 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052387 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
  6. "Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3".
  7. Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Düfer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J (December 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature Cell Biology. 10 (12): 1421–30. doi:10.1038/ncb1801. PMID 18978782. S2CID 19925356.
  8. Klose C, Straub I, Riehle M, Ranta F, Krautwurst D, Ullrich S, Meyerhof W, Harteneck C (April 2011). "Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3". British Journal of Pharmacology. 162 (8): 1757–69. doi:10.1111/j.1476-5381.2010.01186.x. PMC 3081119. PMID 21198543.
  9. Straub I, Mohr F, Stab J, Konrad M, Philipp SE, Oberwinkler J, Schaefer M (April 2013). "Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3". British Journal of Pharmacology. 168 (8): 1835–50. doi:10.1111/bph.12076. PMC 3623054. PMID 23190005.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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