GJA10

Gap junction alpha-10 protein, also known as connexin-62 (Cx62), is a protein that in humans is encoded by the GJA10 gene.[4]

GJA10
Identifiers
AliasesGJA10, CX62, gap junction protein alpha 10
External IDsOMIM: 611924 MGI: 1339969 HomoloGene: 7733 GeneCards: GJA10
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q15Start89,894,469 bp[1]
End89,921,760 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84694

14610

Ensembl

ENSG00000135355
ENSG00000288435

ENSMUSG00000051056

UniProt

Q969M2

Q9WUS4

RefSeq (mRNA)

NM_032602

NM_010289

RefSeq (protein)

NP_115991

NP_034419

Location (UCSC)Chr 6: 89.89 – 89.92 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.[4][5]

References
  1. ENSG00000288435 GRCh38: Ensembl release 89: ENSG00000135355, ENSG00000288435 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: gap junction protein".
  5. Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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