CatSper2

CATSPER2
Identifiers
Aliases	CATSPER2, CatSper2, cation channel sperm associated 2
External IDs	OMIM: 607249 MGI: 2387404 HomoloGene: 77423 GeneCards: CATSPER2
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	43,668,118 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	121,413,792 bp[2]
Gene ontology
Molecular function	• calcium activated cation channel activity; • calcium channel activity; • voltage-gated ion channel activity; • ion channel activity; • GO:0001948 protein binding; • voltage-gated sodium channel activity;
Cellular component	• integral component of membrane; • CatSper complex; • cell projection; • membrane; • cell membrane; • cilium; • motile cilium;
Biological process	• cell differentiation; • membrane depolarization during action potential; • regulation of ion transmembrane transport; • ion transport; • multicellular organism development; • calcium ion transmembrane transport; • transmembrane transport; • spermatogenesis; • sperm-egg recognition; • calcium ion transport; • neuronal action potential; • flagellated sperm motility; • sodium ion transmembrane transport; • fertilization; • sperm capacitation; • response to progesterone;
	Sources:Amigo / QuickGO
Orthologs
	117155
	212670
	ENSG00000166762
	ENSMUSG00000033486
	Q96P56
	A2ARP9
	NM_001282309; NM_001282310; NM_054020; NM_172095; NM_172097
	NM_153075
	NP_001269238; NP_001269239; NP_742093
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.[5][6] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.[7]

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.[8]

References

GRCh38: Ensembl release 89: ENSG00000166762 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000033486 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
- "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
"Entrez Gene: CatSper2".

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID 16740636.
Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. doi:10.1038/35098164. PMID 11595929.
Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166762 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033486 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11675491-5] Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.

[pmid16382101-6] Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.

[IUPHAR-DB-7] "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

[8] "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

[entrez-8] "Entrez Gene: CatSper2".

CatSper2

Function

References

Further reading