CYP20A1

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.[5]

CYP20A1
Identifiers
AliasesCYP20A1, CYP-M, cytochrome P450 family 20 subfamily A member 1
External IDsMGI: 1925201 HomoloGene: 18584 GeneCards: CYP20A1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.2Start203,238,940 bp[1]
End203,305,611 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57404

77951

Ensembl

ENSG00000119004

ENSMUSG00000049439

UniProt

Q6UW02

Q8BKE6

RefSeq (mRNA)

NM_020674
NM_177538

NM_030013
NM_001313721

RefSeq (protein)

NP_001300650
NP_084289

Location (UCSC)Chr 2: 203.24 – 203.31 MbChr 1: 60.34 – 60.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in pollutant and drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP20A1 lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.[6]

CYP20A1 has no identified substrate or biological role and is considered an "orphan" P450.

References

  1. GRCh38: Ensembl release 89: ENSG00000119004 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000049439 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  6. "Entrez Gene: CY20A1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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