CYP4X1

CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) is a protein which in humans is encoded by the CYP4X1 gene.[5]

CYP4X1
Identifiers
AliasesCYP4X1, CYPIVX1, cytochrome P450 family 4 subfamily X member 1
External IDsOMIM: 614999 MGI: 1932403 HomoloGene: 75853 GeneCards: CYP4X1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p33|1Start47,023,669 bp[1]
End47,050,751 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

260293

81906

Ensembl

ENSG00000186377

ENSMUSG00000047155

UniProt

Q8N118

Q6A152

RefSeq (mRNA)

NM_178033
NM_001320289
NM_001320290

NM_001003947

RefSeq (protein)

NP_001307218
NP_001307219
NP_828847

NP_001003947

Location (UCSC)Chr 1: 47.02 – 47.05 MbChr 4: 115.11 – 115.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000186377 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047155 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bylund J; Zhang C; Harder DR (August 2002). "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain". Biochem. Biophys. Res. Commun. 296 (3): 677–84. doi:10.1016/S0006-291X(02)00918-X. PMID 12176035.
  6. "Entrez Gene: CYP4X1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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