FER (gene)

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.[5]

FER
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFER, FerT, PPP1R74, Pe1Fe10, Pe1Fe13, Pe1Fe3, Pe1Fe6, TYK3, p94-Fer, FER tyrosine kinase
External IDsOMIM: 176942 MGI: 105917 HomoloGene: 74300 GeneCards: FER
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q21.3Start108,747,841 bp[1]
End109,196,841 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

2241

14158

Ensembl

ENSG00000151422

ENSMUSG00000000127

UniProt

P16591

P70451

RefSeq (mRNA)

NM_001308028
NM_001308031
NM_001308038
NM_005246

NM_001037997
NM_001286415
NM_008000

RefSeq (protein)

NP_001294957
NP_001294960
NP_001294967
NP_005237

NP_001033086
NP_001273344
NP_032026

Location (UCSC)Chr 5: 108.75 – 109.2 MbChr 17: 63.86 – 64.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.[5]

Interactions

FER (gene) has been shown to interact with TMF1[6] and Cortactin.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000151422 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000000127 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)".
  6. Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. NETHERLANDS. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951. S2CID 24338520.
  7. Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER". J. Biol. Chem. UNITED STATES. 273 (36): 23542–8. doi:10.1074/jbc.273.36.23542. ISSN 0021-9258. PMID 9722593.

Further reading


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