Fibroblast growth factor receptor 4

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334).

FGFR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QQ5, 4QQC, 4QQJ, 4QQT, 4QRC, 4R6V, 4TYE, 4TYG, 4TYI, 4TYJ, 4UXQ, 4XCU
Identifiers
Aliases	FGFR4, CD334, JTK2, TKF, fibroblast growth factor receptor 4
External IDs	OMIM: 134935 MGI: 95525 HomoloGene: 20461 GeneCards: FGFR4
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 177,086,905 bp[1] End 177,098,144 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 29.8 cM Start 55,152,640 bp[2] End 55,168,759 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • heparin binding • kinase activity • GO:0001948 protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • fibroblast growth factor binding • fibroblast growth factor-activated receptor activity • ATP binding • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • receptor tyrosine kinase • transmembrane signaling receptor activity Cellular component • integral component of membrane • endosome • Golgi apparatus • membrane • intercellular junction • cell membrane • integral component of plasma membrane • transport vesicle • extracellular region • endoplasmic reticulum • cytoplasm • receptor complex Biological process • glucose homeostasis • phosphorylation • phosphate ion homeostasis • response to bile acid • regulation of extracellular matrix disassembly • MAPK cascade • regulation of bile acid biosynthetic process • fibroblast growth factor receptor signaling pathway • regulation of lipid metabolic process • protein phosphorylation • positive regulation of gene expression • positive regulation of cell proliferation • positive regulation of DNA biosynthetic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of proteolysis • autophosphorylation • peptidyl-tyrosine phosphorylation • cell migration • phosphatidylinositol phosphorylation • GO:0048554 positive regulation of catalytic activity • phosphatidylinositol-3-phosphate biosynthetic process • positive regulation of protein kinase B signaling • cholesterol homeostasis • angiogenesis • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2264	14186
Ensembl	ENSG00000160867	ENSMUSG00000005320
UniProt	P22455	Q03142
RefSeq (mRNA)	NM_001291980 NM_002011 NM_022963 NM_213647 NM_001354984	NM_008011
RefSeq (protein)	NP_001278909 NP_002002 NP_075252 NP_998812 NP_001341913	NP_032037
Location (UCSC)	Chr 5: 177.09 – 177.1 Mb	Chr 13: 55.15 – 55.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.[5] In a meta-analisis study, the functional polymorphism Gly388Arg (rs351855) of FGFR4 was observed to be significantly associated with nodal involvement and overall survival in patients with different types of cancer. [6]