EPHA6

EPHA6
Identifiers
Aliases	EPHA6, EHK-2, EHK2, EK12, EPA6, HEK12, PRO57066, EPH receptor A6
External IDs	OMIM: 600066 MGI: 108034 HomoloGene: 56396 GeneCards: EPHA6
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	97,752,460 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	60,605,531 bp[2]
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • kinase activity; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • ATP binding; • ephrin receptor activity; • molecular function; • receptor tyrosine kinase; • transmembrane signaling receptor activity; • transmembrane-ephrin receptor activity;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • integral component of plasma membrane; • nucleoplasm; • cellular component; • cytoplasm; • neuron projection; • receptor complex;
Biological process	• phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • protein phosphorylation; • peptidyl-tyrosine phosphorylation; • ephrin receptor signaling pathway; • biological process; • negative regulation of signal transduction; • cell differentiation; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	285220
	13840
	ENSG00000080224
	ENSMUSG00000055540
	Q9UF33
	Q62413
	NM_001080448; NM_001278300; NM_001278301; NM_173655
	NM_007938
	NP_001073917; NP_001265229; NP_001265230; NP_775926
	NP_031964
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000080224 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055540 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.
"Entrez Gene: EPHA6 EPH receptor A6".

Wilkinson DG (2000). Eph receptors and ephrins: regulators of guidance and assembly. Int. Rev. Cytol. International Review of Cytology. 196. pp. 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance". Curr. Biol. 14 (3): R121–3. doi:10.1016/j.cub.2004.01.020. PMID 14986683. S2CID 2957639.
Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID 15194108. S2CID 26196696.
Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist : A Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10 (4): 304–14. doi:10.1177/1073858403262221. PMID 15271258. S2CID 23900846.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
Aasheim HC, Munthe E, Funderud S, et al. (2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". Blood. 95 (1): 221–30. doi:10.1182/blood.V95.1.221. PMID 10607706.
Prevost N, Woulfe D, Tanaka T, Brass LF (2002). "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9219–24. doi:10.1073/pnas.142053899. PMC 123121. PMID 12084815.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hafner C, Schmitz G, Meyer S, et al. (2004). "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers". Clin. Chem. 50 (3): 490–9. doi:10.1373/clinchem.2003.026849. PMID 14726470.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

Overview of all the structural information available in the PDB for UniProt: Q62413 (Mouse Ephrin type-A receptor 6) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080224 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055540 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12471243-5] Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.

[entrez-6] "Entrez Gene: EPHA6 EPH receptor A6".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

EPHA6

References

Further reading

External links