INSRR

INSRR
Identifiers
Aliases	INSRR, IRR, insulin receptor related receptor
External IDs	OMIM: 147671 MGI: 1346037 HomoloGene: 56539 GeneCards: INSRR
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	156,859,117 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	87,816,101 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transmembrane receptor protein tyrosine kinase activity; • phosphatidylinositol 3-kinase binding; • insulin receptor substrate binding; • nucleotide binding; • protein kinase activity; • protein tyrosine kinase activity; • transferase activity; • ATP binding; • kinase activity; • receptor tyrosine kinase; • transmembrane signaling receptor activity; • insulin-activated receptor activity;
Cellular component	• receptor complex; • integral component of membrane; • integral component of plasma membrane; • membrane; • cytoplasm; • insulin receptor complex; • axon;
Biological process	• actin cytoskeleton reorganization; • autophosphorylation; • protein phosphorylation; • cellular response to alkaline pH; • male sex determination; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • peptidyl-tyrosine phosphorylation; • insulin receptor signaling pathway; • negative regulation of signal transduction; • cell differentiation; • glucose homeostasis; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	3645
	23920
	ENSG00000027644
	ENSMUSG00000005640
	P14616
	Q9WTL4
	NM_014215
	NM_011832
	NP_055030
	NP_035962
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000027644 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000005640 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shier P, Watt VM (Oct 1989). "Primary structure of a putative receptor for a ligand of the insulin family". J Biol Chem. 264 (25): 14605–8. doi:10.1016/S0021-9258(18)63737-8. PMID 2768234.
Shier P, Willard HF, Watt VM (Jan 1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1". Cytogenet Cell Genet. 54 (1–2): 80–1. doi:10.1159/000132963. PMID 2249481.
"Entrez Gene: INSRR insulin receptor-related receptor".

Zhang B, Roth RA (1992). "The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities". J. Biol. Chem. 267 (26): 18320–8. doi:10.1016/S0021-9258(19)36963-7. PMID 1326521.
Mathi SK, Chan J, Watt VM (1995). "Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney". Endocrinology. 136 (9): 4125–32. doi:10.1210/en.136.9.4125. PMID 7649121.
Kovacina KS, Roth RA (1995). "Characterization of the endogenous insulin receptor-related receptor in neuroblastomas". J. Biol. Chem. 270 (4): 1881–7. doi:10.1074/jbc.270.4.1881. PMID 7829525.
Jui HY, Accili D, Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells". Biochemistry. 35 (45): 14326–30. doi:10.1021/bi9613032. PMID 8916919.
Hänze J, Berthold A, Klammt J, et al. (1999). "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor". Horm. Metab. Res. 31 (2–3): 77–9. doi:10.1055/s-2007-978702. PMID 10226785.
Xu P, Jacobs AR, Taylor SI (1999). "Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins". J. Biol. Chem. 274 (21): 15262–70. doi:10.1074/jbc.274.21.15262. PMID 10329736.
Elmlinger MW, Rauschnabel U, Koscielniak E, et al. (1999). "Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin". Regul. Pept. 84 (1–3): 37–42. doi:10.1016/S0167-0115(99)00065-8. PMID 10535406. S2CID 664805.
Whitmore TE, Maurer MF, Day HL, et al. (2000). "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21→q23 by the use of radiation hybrid mapping". Cytogenet. Cell Genet. 87 (1–2): 93–4. doi:10.1159/000015400. PMID 10640820. S2CID 36476566.
Weber A, Huesken C, Bergmann E, et al. (2004). "Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas". Clin. Cancer Res. 9 (15): 5683–92. PMID 14654552.
Klammt J, Garten A, Barnikol-Oettler A, et al. (2005). "Comparative analysis of the signaling capabilities of the insulin receptor-related receptor". Biochem. Biophys. Res. Commun. 327 (2): 557–64. doi:10.1016/j.bbrc.2004.12.039. PMID 15629149.
Dissen GA, Garcia-Rudaz C, Tapia V, et al. (2006). "Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary". Endocrinology. 147 (1): 155–65. doi:10.1210/en.2005-0386. PMID 16195402.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000027644 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005640 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2768234-5] Shier P, Watt VM (Oct 1989). "Primary structure of a putative receptor for a ligand of the insulin family". J Biol Chem. 264 (25): 14605–8. doi:10.1016/S0021-9258(18)63737-8. PMID 2768234.

[pmid2249481-6] Shier P, Willard HF, Watt VM (Jan 1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1". Cytogenet Cell Genet. 54 (1–2): 80–1. doi:10.1159/000132963. PMID 2249481.

[entrez-7] "Entrez Gene: INSRR insulin receptor-related receptor".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

INSRR

References

Further reading