EPHB6

EPHB6
Identifiers
Aliases	EPHB6, HEP, EPH receptor B6
External IDs	OMIM: 602757 MGI: 1096338 HomoloGene: 20940 GeneCards: EPHB6
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	142,871,094 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	41,620,509 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • protein kinase activity; • GO:0001948 protein binding; • ATP binding; • ephrin receptor activity; • signaling receptor activity; • protein tyrosine kinase activity; • receptor tyrosine kinase; • transmembrane signaling receptor activity; • transmembrane-ephrin receptor activity; • transmembrane receptor protein tyrosine kinase activity;
Cellular component	• integral component of membrane; • extracellular region; • cytosol; • cell membrane; • integral component of plasma membrane; • membrane; • cytoplasm; • neuron projection; • receptor complex;
Biological process	• protein phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • ephrin receptor signaling pathway; • peptidyl-tyrosine phosphorylation; • negative regulation of signal transduction; • cell differentiation; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	2051
	13848
	ENSG00000106123; ENSG00000275482
	ENSMUSG00000029869
	O15197
	O08644
	NM_001280794; NM_001280795; NM_004445
	NM_001146351; NM_007680
	NP_001267723; NP_001267724; NP_004436
	NP_001139823; NP_031706
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.[5]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.[5]

References

ENSG00000275482 GRCh38: Ensembl release 89: ENSG00000106123, ENSG00000275482 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029869 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: EPHB6 EPH receptor B6".

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly; Chapter: Eph receptors and ephrins: Regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Matsuoka H, Iwata N, Ito M, et al. (1997). "Expression of a kinase-defective Eph-like receptor in the normal human brain". Biochem. Biophys. Res. Commun. 235 (3): 487–92. doi:10.1006/bbrc.1997.6812. PMID 9207182.
Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
Munthe E, Rian E, Holien T, et al. (2000). "Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6". FEBS Lett. 466 (1): 169–74. doi:10.1016/S0014-5793(99)01793-7. PMID 10648835. S2CID 40328521.
Shimoyama M, Matsuoka H, Tamekane A, et al. (2000). "T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells". Growth Factors. 18 (1): 63–78. doi:10.3109/08977190009003234. PMID 10831073. S2CID 9397812.
Tang XX, Zhao H, Robinson ME, et al. (2000). "Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10936–41. doi:10.1073/pnas.190123297. PMC 27127. PMID 10984508.
Luo H, Wan X, Wu Y, Wu J (2001). "Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells". J. Immunol. 167 (3): 1362–70. doi:10.4049/jimmunol.167.3.1362. PMID 11466354.

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[refGRCh38Ensembl-1] ENSG00000275482 GRCh38: Ensembl release 89: ENSG00000106123, ENSG00000275482 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029869 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EPHB6 EPH receptor B6".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

EPHB6

References

Further reading