YES1

Proto-oncogene tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.[5][6]

YES1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesYES1, HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
External IDsOMIM: 164880 MGI: 99147 HomoloGene: 55900 GeneCards: YES1
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18p11.32Start721,588 bp[1]
End812,546 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7525

22612

Ensembl

ENSG00000176105

ENSMUSG00000014932

UniProt

P07947

Q04736

RefSeq (mRNA)

NM_005433

NM_001205132
NM_001205133
NM_009535

RefSeq (protein)

NP_005424

NP_001192061
NP_001192062
NP_033561

Location (UCSC)Chr 18: 0.72 – 0.81 MbChr 5: 32.61 – 32.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.[6]

Interactions

YES1 has been shown to interact with Janus kinase 2,[7] CTNND1,[8] RPL10[9] and Occludin.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000176105 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000014932 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40. Bibcode:1985Sci...227.1038S. doi:10.1126/science.2983418. PMID 2983418.
  6. "Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1".
  7. Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. 224 (2): 289–96. doi:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385.
  8. Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction" (PDF). Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114.
  9. Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. 277 (39): 36489–98. doi:10.1074/jbc.M201859200. ISSN 0021-9258. PMID 12138090.
  10. Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells". Mol. Biol. Cell. 13 (4): 1227–37. doi:10.1091/mbc.01-08-0423. ISSN 1059-1524. PMC 102264. PMID 11950934.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P07947 (Tyrosine-protein kinase Yes) at the PDBe-KB.


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