TEC (gene)

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[5][6]

TEC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTEC, PSCTK4, tec protein tyrosine kinase
External IDsOMIM: 600583 MGI: 98662 HomoloGene: 1302 GeneCards: TEC
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4p12-p11Start48,135,783 bp[1]
End48,269,838 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7006

21682

Ensembl

ENSG00000135605

ENSMUSG00000029217

UniProt

P42680

P24604

RefSeq (mRNA)

NM_003215

NM_001113460
NM_001113461
NM_001113464
NM_013689

RefSeq (protein)

NP_003206

NP_001106931
NP_001106932
NP_001106935
NP_038717

Location (UCSC)Chr 4: 48.14 – 48.27 MbChr 5: 72.76 – 72.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[6]

Interactions

TEC (gene) has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000135605 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029217 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (Oct 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID 7934162.
  6. "Entrez Gene: TEC tec protein tyrosine kinase".
  7. Suzuki N, Nakamura S, Mano H, Kozasa T (Jan 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  8. van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (Nov 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10): 3406–13. doi:10.1182/blood.V96.10.3406. PMID 11071635.
  9. Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology. 14 (12): 8432–7. doi:10.1128/MCB.14.12.8432. PMC 359382. PMID 7526158.
  10. Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". The Journal of Biological Chemistry. 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID 11825908.
  11. Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
  12. Yamashita Y, Watanabe S, Miyazato A, Ohya Ki, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (Mar 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood. 91 (5): 1496–507. doi:10.1182/blood.V91.5.1496. PMID 9473212.
  13. Ohya Ki, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (Oct 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". The Journal of Biological Chemistry. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P42680 (Human Tyrosine-protein kinase Tec) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: P24604 (Mouse Tyrosine-protein kinase Tec) at the PDBe-KB.


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