Receptor tyrosine kinase-like orphan receptor
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity. ROR proteins (ROR1 and ROR2 in humans) can modulate Wnt signaling by sequestering Wnt ligands.[1]
| Receptor tyrosine kinase-like orphan receptor | |
|---|---|
| Identifiers | |
| Symbol | ROR |
| InterPro | IPR016247 |
| Membranome | 720 |
| receptor tyrosine kinase-like orphan receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ROR1 | ||||||
| Alt. symbols | NTRKR1 | ||||||
| NCBI gene | 4919 | ||||||
| HGNC | 10256 | ||||||
| OMIM | 602336 | ||||||
| RefSeq | NM_005012 | ||||||
| UniProt | Q01973 | ||||||
| Other data | |||||||
| EC number | 2.7.10.1 | ||||||
| Locus | Chr. 1 p32-p31 | ||||||
| |||||||
| receptor tyrosine kinase-like orphan receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ROR2 | ||||||
| Alt. symbols | NTRKR2, BDB, BDB1 | ||||||
| NCBI gene | 4920 | ||||||
| HGNC | 10257 | ||||||
| OMIM | 602337 | ||||||
| RefSeq | NM_004560 | ||||||
| UniProt | Q01974 | ||||||
| Other data | |||||||
| Locus | Chr. 9 q22 | ||||||
| |||||||
References
- Green JL, Kuntz SG, Sternberg PW (November 2008). "Ror receptor tyrosine kinases: orphans no more". Trends Cell Biol. 18 (11): 536–44. doi:10.1016/j.tcb.2008.08.006. PMC 4672995. PMID 18848778.
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