Rimegepant

Rimegepant, sold under the brand name Nurtec ODT, is a medication for the treatment of an acute migraine with or without aura in adults.[1] It is not used prophylactically.[2]

Rimegepant
Clinical data
Trade namesNurtec ODT
Other namesBHV-3000, BMS-927711
AHFS/Drugs.comMonograph
MedlinePlusa620031
License data
Routes of
administration
By mouth
Drug classcalcitonin gene-related peptide receptor antagonist
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H28F2N6O3
Molar mass534.568 g·mol−1
3D model (JSmol)

Taken by mouth to dissolve on or under the tongue,[2] rimegepant takes effect within an hour and can provide relief from migraine headache for up to 48 hours. It is not a narcotic and has no addictive potential; thus it is not designated as a controlled substance. It works by blocking CGRP receptors.

Approved for use in the United States in February 2020, rimegepant is produced and marketed by Biohaven Pharmaceuticals, based in New Haven, Connecticut.[3][1]

Mechanism of action

Rimegepant is a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist.[4]

History

Originally discovered at Bristol-Myers Squibb,[5] rimegepant was developed by Biohaven Pharmaceuticals, which markets the drug in the United States after receiving FDA approval in February 2020.[6] Approval was based on evidence from one clinical trial of 1,351 subjects with migraine headaches.[1]

References

  1. "Drug Trials Snapshots: Nurtec ODT". U.S. Food and Drug Administration (FDA). 27 February 2020. Retrieved 19 March 2020. This article incorporates text from this source, which is in the public domain.
  2. "Nurtec ODT - rimegepant sulfate tablet, orally disintegrating". DailyMed. 19 February 2020. Retrieved 19 March 2020.
  3. "Nurtec ODT: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 28 February 2020.
  4. Diener HC, Charles A, Goadsby PJ, Holle D (October 2015). "New therapeutic approaches for the prevention and treatment of migraine". The Lancet. Neurology. 14 (10): 1010–22. doi:10.1016/S1474-4422(15)00198-2. PMID 26376968. S2CID 26523013.
  5. "Rimegepant - Biohaven Pharmaceuticals Holding Company". Adis Insight. Springer Nature Switzerland AG.
  6. "Biohaven's Nurtec ODT (rimegepant) Receives FDA Approval for the Acute Treatment of Migraine in Adults" (Press release). Biohaven Pharmaceuticals Holding Company Ltd. 27 February 2020 via PR Newswire.


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