Melanin-concentrating hormone receptor 2

Melanin-concentrating hormone receptor 2 (MCH2) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.[3][4][5]

MCHR2
Identifiers
AliasesMCHR2, GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT, melanin concentrating hormone receptor 2
External IDsOMIM: 606111 HomoloGene: 50004 GeneCards: MCHR2
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q16.2Start99,918,519 bp[1]
End99,994,247 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84539

n/a

Ensembl

ENSG00000152034

n/a

UniProt

Q969V1

n/a

RefSeq (mRNA)

NM_032503
NM_001040179

n/a

RefSeq (protein)

NP_001035269
NP_115892

n/a

Location (UCSC)Chr 6: 99.92 – 99.99 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

MCH2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.

Clinical significance

Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000152034 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2".
  4. Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M (May 2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.
  5. Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI (June 2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.
  6. Zhang Q, Yuan CF, Wu MJ, Wang YG, Qin Q, Shi YY, Liu GL, Song FZ (June 2010). "Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction". Horm. Metab. Res. 42 (7): 521–7. doi:10.1055/s-0030-1249019. PMID 20340065.

Further reading


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