GW-803430
GW-803430 (GW-3430) is a drug used in scientific research and is a selective non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has anxiolytic, antidepressant and anorectic effects.[1][2]
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| ECHA InfoCard | 100.230.542  |
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| Formula | C25H24ClN3O3S |
| Molar mass | 482.00 g·mol−1 |
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References
- Chaki S, Kanuma K (2007). "Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders". Drugs of the Future. 32 (9): 809.
- Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, Craft L, et al. (May 2009). "Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression". The Journal of Pharmacology and Experimental Therapeutics. 329 (2): 429–38. doi:10.1124/jpet.108.143362. PMID 19182070. S2CID 7770969.
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| GABAAR PAMs |
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| Gabapentinoids (α2δ VDCC blockers) | |
| Antidepressants |
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| CRH |
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| Endothelin |
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| Galanin |
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| Glucagon |
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| Insulin |
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| Kisspeptin |
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| Leptin |
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| MCH |
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| Melanocortin |
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| mTOR |
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| Neuropeptide FF |
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| Neuropeptide S |
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| Neuropeptide Y |
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| PTH |
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