Befunolol

Befunolol
Clinical data
Trade names	Benfuran, Bentos, Betaclar, Glauconex
AHFS/Drugs.com	International Drug Names
ATC code	S01ED06 (WHO) ;
Identifiers
	IUPAC name (RS)-1-{7-[2-hydroxy-3-(propan-2-ylamino)propoxy]- 1-benzofuran-2-yl}ethanone;
CAS Number	39552-01-7 ;
PubChem CID	2309;
DrugBank	DB09013 ;
ChemSpider	2219 ;
UNII	418546MT3A;
KEGG	D07496 ;
ChEMBL	ChEMBL153984 ;
Chemical and physical data
Formula	C16H21NO4
Molar mass	291.347 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c2oc1c(OCC(O)CNC(C)C)cccc1c2)C;
	InChI InChI=1S/C16H21NO4/c1-10(2)17-8-13(19)9-20-14-6-4-5-12-7-15(11(3)18)21-16(12)14/h4-7,10,13,17,19H,8-9H2,1-3H3 ; Key:ZPQPDBIHYCBNIG-UHFFFAOYSA-N ;
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Befunolol (INN) is a beta blocker with intrinsic sympathomimetic activity used in the management of open-angle glaucoma.[1] It also acts as a β adrenoreceptor partial agonist.[2][3] Befunolol was introduced in Japan in 1983 by Kakenyaku Kako Co. under the trade name Bentos.[4]

References

Reichl S, Müller-Goymann CC (January 2003). "The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride". International Journal of Pharmaceutics. 250 (1): 191–201. doi:10.1016/S0378-5173(02)00541-0. PMID 12480285.
Koike K, Takayanagi I (October 1986). "A beta-adrenergic partial agonist (befunolol) discriminates two different affinity sites". Japanese Journal of Pharmacology. 42 (2): 325–8. doi:10.1254/jjp.42.325. PMID 2879061.
Takayanagi I, Koike K (January 1985). "A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs". General Pharmacology. 16 (3): 265–7. doi:10.1016/0306-3623(85)90080-1. PMID 2862092.
Pharmaceutical Manufacturing Encyclopedia (3rd revised ed.). Norwich, N.Y.: William Andrew Publishing. January 14, 2008. p. 542. ISBN 978-0815515265.

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