ACP1

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.

ACP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACP1, HAAP, LMW-PTP, acid phosphatase 1, soluble, LMWPTP, acid phosphatase 1
External IDsOMIM: 171500 MGI: 87881 HomoloGene: 38274 GeneCards: ACP1
EC number3.1.3.2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p25.3Start264,140 bp[1]
End278,283 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

52

11431

Ensembl

ENSG00000143727

ENSMUSG00000044573

UniProt

P24666

Q9D358

RefSeq (mRNA)

NM_001040649
NM_004300
NM_007099
NM_177554

NM_001110239
NM_021330

RefSeq (protein)

NP_001035739
NP_004291
NP_009030

NP_001103709
NP_067305

Location (UCSC)Chr 2: 0.26 – 0.28 MbChr 12: 30.89 – 30.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.[5]

Interactions

ACP1 has been shown to interact with EPH receptor A2[6] and EPH receptor B1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000143727 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044573 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ACP1 acid phosphatase 1, soluble".
  6. Kikawa, Keith D; Vidale Derika R; Van Etten Robert L; Kinch Michael S (October 2002). "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". J. Biol. Chem. United States. 277 (42): 39274–9. doi:10.1074/jbc.M207127200. ISSN 0021-9258. PMID 12167657.
  7. Stein, E; Lane A A; Cerretti D P; Schoecklmann H O; Schroff A D; Van Etten R L; Daniel T O (March 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes Dev. UNITED STATES. 12 (5): 667–78. doi:10.1101/gad.12.5.667. ISSN 0890-9369. PMC 316584. PMID 9499402.
  • Human ACP1 genome location and ACP1 gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: P24666 (Human Low molecular weight phosphotyrosine protein phosphatase) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q9D358 (Mouse Low molecular weight phosphotyrosine protein phosphatase) at the PDBe-KB.

Further reading

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