SSH1

For the SSH-1 protocol, see Secure Shell#Version 1.x

SSH1
Identifiers
AliasesSSH1, SSH1L, slingshot protein phosphatase 1
External IDsOMIM: 606778 MGI: 2686240 HomoloGene: 41299 GeneCards: SSH1
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q24.11Start108,778,191 bp[1]
End108,857,590 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54434

231637

Ensembl

ENSG00000084112

ENSMUSG00000042121

UniProt

Q8WYL5

Q76I79

RefSeq (mRNA)

NM_001161330
NM_001161331
NM_018984

NM_198109
NM_001363469

RefSeq (protein)

NP_001154802
NP_001154803
NP_061857

NP_932777
NP_001350398

Location (UCSC)Chr 12: 108.78 – 108.86 MbChr 5: 113.94 – 113.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.[5][6][7]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000084112 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042121 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  6. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.
  7. "Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)".

Further reading

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