PTPN14

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.[5][6]

PTPN14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN14, PEZ, PTP36, protein tyrosine phosphatase, non-receptor type 14, CATLPH, protein tyrosine phosphatase non-receptor type 14
External IDsOMIM: 603155 MGI: 102467 HomoloGene: 3941 GeneCards: PTPN14
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q32.3-q41Start214,348,700 bp[1]
End214,552,449 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5784

19250

Ensembl

ENSG00000152104

ENSMUSG00000026604

UniProt

Q15678

Q62130

RefSeq (mRNA)

NM_005401

NM_001033287
NM_008976

RefSeq (protein)

NP_005392

NP_033002

Location (UCSC)Chr 1: 214.35 – 214.55 MbChr 1: 189.73 – 189.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.[6]

Interactions

PTPN14 has been shown to interact with Beta-catenin.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000152104 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026604 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (Apr 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochemical and Biophysical Research Communications. 209 (3): 959–65. doi:10.1006/bbrc.1995.1591. PMID 7733990.
  6. "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14".
  7. Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14)


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