DUSP12

Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.[5][6]

DUSP12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JNB, 4KI9
Identifiers
Aliases	DUSP12, DUSP1, YVH1, dual specificity phosphatase 12
External IDs	OMIM: 604835 MGI: 1890614 HomoloGene: 5238 GeneCards: DUSP12
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,749,758 bp[1] End 161,757,238 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,873,498 bp[2] End 170,885,540 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein tyrosine phosphatase activity • GO:0001948 protein binding • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • metal ion binding • zinc ion binding • phosphatase activity • nucleic acid binding • kinase binding Cellular component • cytosol • cell nucleus • cytoplasm Biological process • protein dephosphorylation • cellular protein modification process • positive regulation of glucokinase activity • peptidyl-tyrosine dephosphorylation • dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11266	80915
Ensembl	ENSG00000081721	ENSMUSG00000026659
UniProt	Q9UNI6	Q9D0T2
RefSeq (mRNA)	NM_007240	NM_023173
RefSeq (protein)	NP_009171	NP_075662 NP_001343414 NP_001343415
Location (UCSC)	Chr 1: 161.75 – 161.76 Mb	Chr 1: 170.87 – 170.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.[6]