PTPN13

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.[5][6]

PTPN13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN13, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E, protein tyrosine phosphatase, non-receptor type 13, protein tyrosine phosphatase non-receptor type 13
External IDsOMIM: 600267 MGI: 103293 HomoloGene: 7909 GeneCards: PTPN13
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q21.3Start86,594,315 bp[1]
End86,815,171 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5783

19249

Ensembl

ENSG00000163629

ENSMUSG00000034573

UniProt

Q12923

Q64512

RefSeq (mRNA)

NM_006264
NM_080683
NM_080684
NM_080685

NM_011204

RefSeq (protein)

NP_006255
NP_542414
NP_542415
NP_542416

NP_035334

Location (UCSC)Chr 4: 86.59 – 86.82 MbChr 5: 103.43 – 103.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.[6]

Interactions

PTPN13 has been shown to interact with PKN2.[7]

References

Further reading

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