PTPRJ

Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.[5][6][7]

PTPRJ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPRJ, CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, protein tyrosine phosphatase, receptor type J, protein tyrosine phosphatase receptor type J
External IDsOMIM: 600925 MGI: 104574 HomoloGene: 2130 GeneCards: PTPRJ
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p11.2Start47,980,558 bp[1]
End48,170,841 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5795

19271

Ensembl

ENSG00000149177

ENSMUSG00000025314

UniProt

Q12913

Q64455

RefSeq (mRNA)

NM_001098503
NM_002843

NM_001135657
NM_008982

RefSeq (protein)

NP_001091973
NP_002834

NP_001129129
NP_033008

Location (UCSC)Chr 11: 47.98 – 48.17 MbChr 2: 90.43 – 90.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.[7]

Interactions

PTPRJ has been shown to interact with CTNND1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000149177 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025314 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ostman A, Yang Q, Tonks NK (Nov 1994). "Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density". Proc Natl Acad Sci U S A. 91 (21): 9680–4. doi:10.1073/pnas.91.21.9680. PMC 44880. PMID 7937872.
  6. Honda H, Inazawa J, Nishida J, Yazaki Y, Hirai H (Jan 1995). "Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta". Blood. 84 (12): 4186–94. doi:10.1182/blood.V84.12.4186.bloodjournal84124186. PMID 7994032.
  7. "Entrez Gene: PTPRJ protein tyrosine phosphatase, receptor type, J".
  8. Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (Oct 2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. doi:10.1038/sj.onc.1205858. PMID 12370829.

Further reading


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