SSH2

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.[5][6][7]

SSH2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSSH2, SSH-2, SSH-2L, slingshot protein phosphatase 2
External IDsOMIM: 606779 MGI: 2679255 HomoloGene: 14116 GeneCards: SSH2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q11.2Start29,625,938 bp[1]
End29,930,276 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

85464

237860

Ensembl

ENSG00000141298

ENSMUSG00000037926

UniProt

Q76I76

Q5SW75

RefSeq (mRNA)

NM_001282129
NM_001282130
NM_001282131
NM_033389

NM_001291190
NM_177710

RefSeq (protein)

NP_001269058
NP_001269059
NP_001269060
NP_203747

NP_001278119
NP_808378

Location (UCSC)Chr 17: 29.63 – 29.93 MbChr 11: 77.22 – 77.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
For the SSH-2 protocol, see Secure Shell#Version 2.x

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000141298 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037926 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.
  6. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  7. "Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q76I76 (Protein phosphatase Slingshot homolog 2) at the PDBe-KB.


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