PTPRG

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.[5][6]

PTPRG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPRG, HPTPG, PTPG, R-PTP-GAMMA, RPTPG, protein tyrosine phosphatase, receptor type G, protein tyrosine phosphatase receptor type G
External IDsOMIM: 176886 MGI: 97814 HomoloGene: 2129 GeneCards: PTPRG
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p14.2Start61,561,569 bp[1]
End62,297,609 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5793

19270

Ensembl

ENSG00000144724

ENSMUSG00000021745

UniProt

P23470

Q05909

RefSeq (mRNA)

NM_002841
NM_001375471

NM_008981
NM_001347593

RefSeq (protein)

NP_002832
NP_001362400

NP_001334522
NP_033007

Location (UCSC)Chr 3: 61.56 – 62.3 MbChr 14: 11.55 – 12.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000144724 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021745 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. LaForgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Glick J, Weston A, et al. (Jul 1991). "Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21". Proc Natl Acad Sci U S A. 88 (11): 5036–40. doi:10.1073/pnas.88.11.5036. PMC 51802. PMID 1711217.
  6. "Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G".

Further reading


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