EEF1B2

Elongation factor 1-beta is a protein that in humans is encoded by the EEF1B2 gene.[5][6]

EEF1B2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEEF1B2, EEF1B, EEF1B1, EF1B, eukaryotic translation elongation factor 1 beta 2
External IDsOMIM: 600655 MGI: 1929520 HomoloGene: 1480 GeneCards: EEF1B2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.3Start206,159,585 bp[1]
End206,162,928 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1933

55949

Ensembl

ENSG00000114942
ENSG00000283391

ENSMUSG00000025967

UniProt

P24534

O70251

RefSeq (mRNA)

NM_021121
NM_001037663
NM_001959

NM_018796

RefSeq (protein)

NP_001032752
NP_001950
NP_066944

NP_061266

Location (UCSC)Chr 2: 206.16 – 206.16 MbChr 1: 63.18 – 63.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR.[6]

Interactions

EEF1B2 has been shown to interact with EEF1G[7][8] and HARS.[9]

References

  1. ENSG00000283391 GRCh38: Ensembl release 89: ENSG00000114942, ENSG00000283391 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025967 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pizzuti A, Gennarelli M, Novelli G, Colosimo A, Lo Cicero S, Caskey CT, Dallapiccola B (Nov 1993). "Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X". Biochemical and Biophysical Research Communications. 197 (1): 154–62. doi:10.1006/bbrc.1993.2454. PMID 8250921.
  6. "Entrez Gene: EEF1B2 eukaryotic translation elongation factor 1 beta 2".
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  8. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  9. Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.

Further reading


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