MRPL20

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.[4]

MRPL20
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL20, L20mt, MRP-L20, mitochondrial ribosomal protein L20
External IDsOMIM: 611833 MGI: 2137221 HomoloGene: 9941 GeneCards: MRPL20
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.33Start1,401,909 bp[1]
End1,407,293 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55052

66448

Ensembl

ENSG00000242485

ENSMUSG00000029066

UniProt

Q9BYC9

Q9CQL4

RefSeq (mRNA)

NM_017971
NM_001318485

NM_025570

RefSeq (protein)

NP_001305414
NP_060441

NP_079846

Location (UCSC)Chr 1: 1.4 – 1.41 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q.[4]

References

  1. GRCh38: Ensembl release 89: ENSG00000242485 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: MRPL20 mitochondrial ribosomal protein L20".

Further reading


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