MRPS26

28S ribosomal protein S26, mitochondrial is a protein that in humans is encoded by the MRPS26 gene.[4][5]

MRPS26
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS26, C20orf193, GI008, MRP-S13, MRP-S26, MRPS13, NY-BR-87, RPMS13, dJ534B8.3, mitochondrial ribosomal protein S26
External IDsOMIM: 611988 MGI: 1333830 HomoloGene: 12778 GeneCards: MRPS26
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20p13Start3,046,052 bp[1]
End3,048,250 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64949

99045

Ensembl

ENSG00000125901

ENSMUSG00000037740

UniProt

Q9BYN8

Q80ZS3

RefSeq (mRNA)

NM_030811

NM_207207

RefSeq (protein)

NP_110438

NP_997090

Location (UCSC)Chr 20: 3.05 – 3.05 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000125901 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  5. "Entrez Gene: MRPS26 mitochondrial ribosomal protein S26".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9BYN8 (28S ribosomal protein S26, mitochondrial) at the PDBe-KB.
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