MRPS26

28S ribosomal protein S26, mitochondrial is a protein that in humans is encoded by the MRPS26 gene.[4][5]

MRPS26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS26, C20orf193, GI008, MRP-S13, MRP-S26, MRPS13, NY-BR-87, RPMS13, dJ534B8.3, mitochondrial ribosomal protein S26
External IDs	OMIM: 611988 MGI: 1333830 HomoloGene: 12778 GeneCards: MRPS26
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,046,052 bp[1] End 3,048,250 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA binding Cellular component • mitochondrial inner membrane • ribosome • mitochondrial small ribosomal subunit • nucleoplasm • mitochondrion Biological process • peptide biosynthetic process • mitochondrial translational elongation • mitochondrial translational termination • DNA damage response, detection of DNA damage Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64949	99045
Ensembl	ENSG00000125901	ENSMUSG00000037740
UniProt	Q9BYN8	Q80ZS3
RefSeq (mRNA)	NM_030811	NM_207207
RefSeq (protein)	NP_110438	NP_997090
Location (UCSC)	Chr 20: 3.05 – 3.05 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene.[5]