EIF3K

Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene.[5][6][7]

EIF3K
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF3K, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001, ARG134, eukaryotic translation initiation factor 3 subunit K
External IDsOMIM: 609596 MGI: 1921080 HomoloGene: 8292 GeneCards: EIF3K
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.2Start38,619,082 bp[1]
End38,636,955 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27335

73830

Ensembl

ENSG00000178982
ENSG00000282986

ENSMUSG00000053565

UniProt

Q9UBQ5

Q9DBZ5

RefSeq (mRNA)

NM_001300992
NM_001308393
NM_013234

NM_001285942
NM_001285943
NM_028659

RefSeq (protein)

NP_001287921
NP_001295322
NP_037366

NP_001272871
NP_001272872
NP_082935

Location (UCSC)Chr 19: 38.62 – 38.64 MbChr 7: 28.97 – 28.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 43S preinitiation complex.[8][7]

Interactions

eIF3k has been shown to interact with Cyclin D3[9] and eIF3a.[6][10]

See also

References
  1. ENSG00000282986 GRCh38: Ensembl release 89: ENSG00000178982, ENSG00000282986 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053565 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
  7. "Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12".
  8. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
  9. Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (August 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3 (eIF3k) as a new interaction partner of cyclin D3". FEBS Letters. 573 (1–3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989. S2CID 16005938.
  10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading
  • Overview of all the structural information available in the PDB for UniProt: Q9UBQ5 (Human Eukaryotic translation initiation factor 3 subunit K (EIF3K)) at the PDBe-KB.
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