MRPL4

39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene.[5]

MRPL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M,%%s3J7Y, 3J9M
Identifiers
Aliases	MRPL4, CGI-28, L4mt, mitochondrial ribosomal protein L4
External IDs	OMIM: 611823 MGI: 2137210 HomoloGene: 32286 GeneCards: MRPL4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,251,901 bp[1] End 10,260,055 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 21,002,738 bp[2] End 21,008,839 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural constituent of ribosome • GO:0001948 protein binding • RNA binding Cellular component • mitochondrial inner membrane • ribosome • mitochondrion • cytosolic ribosome • mitochondrial large ribosomal subunit Biological process • mitochondrial translational elongation • mitochondrial translational termination • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51073	66163
Ensembl	ENSG00000105364	ENSMUSG00000003299
UniProt	Q9BYD3	Q9DCU6
RefSeq (mRNA)	NM_015956 NM_146387 NM_146388	NM_023167 NM_001357899
RefSeq (protein)	NP_057040 NP_666499 NP_666500 NP_057040.2 NP_666499.1	NP_075656 NP_001344828
Location (UCSC)	Chr 19: 10.25 – 10.26 Mb	Chr 9: 21 – 21.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms.[5]