MRPS30

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.[4][5][6]

MRPS30
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS30, MRP-S30, PAP, PDCD9, S30mt, mitochondrial ribosomal protein S30
External IDsOMIM: 611991 MGI: 1926237 HomoloGene: 9607 GeneCards: MRPS30
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p12Start44,808,947 bp[1]
End44,820,428 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10884

59054

Ensembl

ENSG00000112996

ENSMUSG00000021731

UniProt

Q9NP92

Q9D0G0

RefSeq (mRNA)

NM_016640

NM_021556

RefSeq (protein)

NP_057724

NP_067531

Location (UCSC)Chr 5: 44.81 – 44.82 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000112996 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Carim L, Sumoy L, Nadal M, Estivill X, Escarceller M (May 2000). "Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52". Cytogenet Cell Genet. 87 (1–2): 85–8. doi:10.1159/000015397. PMID 10640817. S2CID 28253818.
  5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. "Entrez Gene: MRPS30 mitochondrial ribosomal protein S30".

Further reading


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