MRPS22

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.[5][6]

MRPS22
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS22, C3orf5, COXPD5, GIBT, MRP-S22, RPMS22, GK002, mitochondrial ribosomal protein S22, ODG7
External IDsOMIM: 605810 MGI: 1928137 HomoloGene: 57030 GeneCards: MRPS22
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q23Start139,005,806 bp[1]
End139,357,223 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56945

64655

Ensembl

ENSG00000175110

ENSMUSG00000032459

UniProt

P82650

Q9CXW2

RefSeq (mRNA)

NM_020191
NM_001363857
NM_001363893

NM_025485

RefSeq (protein)

NP_064576
NP_001350786
NP_001350822

NP_079761

Location (UCSC)Chr 3: 139.01 – 139.36 MbChr 9: 98.59 – 98.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000175110 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032459 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Ristaldi MS, Marzella R, Rocchi M, Nicolino M, Lienhardt-Roussie A, Nivelon A, Verloes A, Schlessinger D, Gasparini P, Bonneau D, Cao A, Pilia G (Feb 2001). "The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome". Nat Genet. 27 (2): 159–66. doi:10.1038/84781. PMID 11175783. S2CID 26750194.
  6. "Entrez Gene: MRPS22 mitochondrial ribosomal protein S22".

Further reading


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