EIF1AX

Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene.[5][6][7] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.[7]

EIF1AX
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF1AX, EIF1A, EIF1AP1, EIF4C, eIF-1A, eIF-4C, eukaryotic translation initiation factor 1A, X-linked, eukaryotic translation initiation factor 1A X-linked
External IDsOMIM: 300186 MGI: 95298 HomoloGene: 20364 GeneCards: EIF1AX
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp22.12Start20,124,525 bp[1]
End20,141,838 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1964

13664

Ensembl

ENSG00000173674

ENSMUSG00000057561

UniProt

P47813

Q60872

RefSeq (mRNA)

NM_001412

NM_010120
NM_001374654

RefSeq (protein)

NP_001403

NP_034250

Location (UCSC)Chr X: 20.12 – 20.14 MbChr 18: 46.6 – 46.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1.[8]

Clinical significance

Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.[9] eIF1A is mutated in thyroid cancers.[10]

Interactions

EIF1AX has been shown to interact with IPO13.[11]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000173674 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000057561 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Feb 1994). "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing". The Journal of Biological Chemistry. 269 (5): 3212–8. PMID 8106356.
  6. Lahn BT, Page DC (Oct 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
  7. "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked".
  8. Fraser, Christopher S. (2015). "Quantitative studies of mRNA recruitment to the eukaryotic ribosome". Biochimie. 114: 58–71. doi:10.1016/j.biochi.2015.02.017. PMC 4458453. PMID 25742741.
  9. Martin M, Maßhöfer L, Temming P, Rahmann S, Metz C, Bornfeld N, van de Nes J, Klein-Hitpass L, Hinnebusch AG, Horsthemke B, Lohmann DR, Zeschnigk M (Aug 2013). "Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3". Nature Genetics. 45 (8): 933–6. doi:10.1038/ng.2674. PMC 4307600. PMID 23793026.
  10. Xu, Yichen; Ruggero, Davide (2020-03-09). "The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications". Annual Review of Cancer Biology. 4 (1): 437–457. doi:10.1146/annurev-cancerbio-030419-033420. ISSN 2472-3428.
  11. Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (Jul 2001). "Importin 13: a novel mediator of nuclear import and export". The EMBO Journal. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMC 125545. PMID 11447110.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P47813 (Eukaryotic translation initiation factor 1A, X-chromosoma) at the PDBe-KB.
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