FGF10

FGF10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NUN
Identifiers
Aliases	FGF10, fibroblast growth factor 10
External IDs	OMIM: 602115 MGI: 1099809 HomoloGene: 3284 GeneCards: FGF10
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	44,389,706 bp[1]
Gene ontology
Molecular function	• heparin binding; • type 2 fibroblast growth factor receptor binding; • growth factor activity; • GO:0001948 protein binding; • fibroblast growth factor receptor binding; • chemoattractant activity; • protein tyrosine kinase activity; • 1-phosphatidylinositol-3-kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • Ras guanyl-nucleotide exchange factor activity;
Cellular component	• extracellular region; • cell nucleus; • cell surface; • extracellular matrix; • cell membrane; • extracellular; • collagen-containing extracellular matrix;
Biological process	• bud outgrowth involved in lung branching; • limb bud formation; • organ growth; • semicircular canal morphogenesis; • embryonic pattern specification; • bud elongation involved in lung branching; • positive regulation of canonical Wnt signaling pathway; • muscle cell fate commitment; • tear secretion; • positive regulation of Ras protein signal transduction; • positive regulation of urothelial cell proliferation; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; • limb development; • radial glial cell differentiation; • female genitalia morphogenesis; • mesonephros development; • odontogenesis of dentin-containing tooth; • prostatic bud formation; • negative regulation of cell cycle arrest; • blood vessel remodeling; • regulation of saliva secretion; • angiogenesis; • establishment of mitotic spindle orientation; • positive regulation of ERK1 and ERK2 cascade; • embryonic digestive tract morphogenesis; • animal organ morphogenesis; • hair follicle morphogenesis; • metanephros development; • lung saccule development; • lung epithelium development; • positive regulation of Notch signaling pathway; • negative regulation of cell proliferation; • branch elongation involved in salivary gland morphogenesis; • branching involved in salivary gland morphogenesis; • positive regulation of white fat cell proliferation; • bronchiole morphogenesis; • limb morphogenesis; • blood vessel morphogenesis; • lung development; • thymus development; • positive regulation of fibroblast proliferation; • negative regulation of cell differentiation; • ERK1 and ERK2 cascade; • positive regulation of epithelial cell migration; • positive regulation of mitotic cell cycle; • spleen development; • smooth muscle cell differentiation; • positive regulation of transcription, DNA-templated; • positive regulation of Wnt signaling pathway; • Harderian gland development; • protein localization to cell surface; • respiratory system development; • epidermis development; • positive regulation of peptidyl-tyrosine phosphorylation; • metanephros morphogenesis; • pancreas development; • mammary gland bud formation; • positive chemotaxis; • mesenchymal-epithelial cell signaling involved in lung development; • positive regulation of hair follicle cell proliferation; • lacrimal gland development; • positive regulation of MAPK cascade; • cell differentiation; • positive regulation of keratinocyte proliferation; • positive regulation of ATPase activity; • positive regulation of epithelial cell proliferation involved in wound healing; • epithelial cell differentiation; • organ induction; • positive regulation of epithelial cell proliferation; • epidermis morphogenesis; • wound healing; • epithelial cell proliferation; • regulation of activin receptor signaling pathway; • positive regulation of DNA replication; • chemotaxis; • embryonic genitalia morphogenesis; • salivary gland development; • positive regulation of keratinocyte migration; • response to lipopolysaccharide; • thyroid gland development; • keratinocyte proliferation; • semicircular canal fusion; • activation of MAPK activity; • mammary gland specification; • epithelial cell migration; • white fat cell differentiation; • regulation of gene expression; • lung alveolus development; • branching morphogenesis of an epithelial tube; • embryonic digestive tract development; • lung proximal/distal axis specification; • fibroblast growth factor receptor signaling pathway involved in mammary gland specification; • actin cytoskeleton reorganization; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • pituitary gland development; • response to estradiol; • secretion by lung epithelial cell involved in lung growth; • mesenchymal cell differentiation involved in lung development; • lung morphogenesis; • response to organic cyclic compound; • somatic stem cell population maintenance; • tissue regeneration; • otic vesicle formation; • epithelial cell proliferation involved in salivary gland morphogenesis; • cell-cell signaling; • male genitalia morphogenesis; • positive regulation of DNA repair; • salivary gland morphogenesis; • MAPK cascade; • embryonic camera-type eye development; • induction of positive chemotaxis; • urothelial cell proliferation; • animal organ formation; • fibroblast growth factor receptor signaling pathway; • regulation of smoothened signaling pathway; • determination of left/right symmetry; • inner ear morphogenesis; • positive regulation of cell proliferation; • submandibular salivary gland formation; • Type II pneumocyte differentiation; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • digestive tract development; • regulation of epithelial cell proliferation; • epithelial tube branching involved in lung morphogenesis; • positive regulation of lymphocyte proliferation; • positive regulation of transcription from RNA polymerase II promoter; • phosphatidylinositol phosphorylation; • phosphatidylinositol-3-phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • regulation of receptor activity; • positive regulation of protein kinase B signaling; • positive regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	2255
	14165
	ENSG00000070193
	ENSMUSG00000021732
	O15520
	O35565
	NM_004465
	NM_008002
	NP_004456
	NP_032028
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.[4][5]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Fibroblast growth factor 10 is a paracrine signaling molecule seen first in the limb bud and organogenesis development. FGF10 starts the developing of limbs and its involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands. During the limb development Tbx4/Tbx5 stimulate the production of FGF10 in the lateral plate mesoderm where it will create an epithelial-mesenchymal FGF signal with FGF8. This positive feedback loop will increase the amount of mesenchyme resulting in a bulge. Afterwards, FGF10 will induce the formation of apical ectodermal ridge (AER) where the foot and hands will be formed. Lung development uses the same epithelial-mesenchymal signaling from FGF10 in the foregut mesenchyme with FGFR2 in the foregut epithelium. FGF10 signaling is required for epithelial branching. Therefore, all branching morphogen organs such as the lungs, skin, ear and salivary glands required the constant expression of FGF10. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7.[5]

Clinical significance

Nonsense mutations may also occur with the absence of FGF10 such as LADD and ALSG syndrome. Nevertheless complications may arise from FGF10 signaling such as pancreatic and breast cancer. Although this gene is also implicated to be a primary factor in the process of wound healing.[5]

Animal studies

FGF10 knockout mice die right after birth. The mice showed no developing organs such as lungs, salivary glands, kidney or definitive limbs once autopsied. Studies of the mouse homolog suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation.[6]

References

GRCh38: Ensembl release 89: ENSG00000070193 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (September 1997). "Structure and expression of human fibroblast growth factor-10". The Journal of Biological Chemistry. 272 (37): 23191–4. doi:10.1074/jbc.272.37.23191. PMID 9287324.
"Entrez Gene: FGF10 fibroblast growth factor 10".
Itoh N, Ohta H (2014). "Fgf10: a paracrine-signaling molecule in development, disease, and regenerative medicine". Current Molecular Medicine. 14 (4): 504–9. doi:10.2174/1566524014666140414204829. PMID 24730525.

External links

OMIM entry on aplasia of lacrimal and salivary glands

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070193 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9287324-4] Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birnbaum D, Coulier F, Itoh N (September 1997). "Structure and expression of human fibroblast growth factor-10". The Journal of Biological Chemistry. 272 (37): 23191–4. doi:10.1074/jbc.272.37.23191. PMID 9287324.

[entrez-5] "Entrez Gene: FGF10 fibroblast growth factor 10".

[Itoh_2014-6] Itoh N, Ohta H (2014). "Fgf10: a paracrine-signaling molecule in development, disease, and regenerative medicine". Current Molecular Medicine. 14 (4): 504–9. doi:10.2174/1566524014666140414204829. PMID 24730525.