Norwogonin
Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap).[1] It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known 7,8-dihydroxyflavone (7,8-DHF).[2]
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| Other names | 5,7,8-Trihydroxyflavone; 5,7,8-THF |
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| Formula | C15H10O5 |
| Molar mass | 270.240 g·mol−1 |
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References
- Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, et al. (2013). Khan AU (ed.). "Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii". PLOS ONE. 8 (4): e61594. Bibcode:2013PLoSO...861594M. doi:10.1371/journal.pone.0061594. PMC 3632535. PMID 23630600.
- Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. (December 2010). "A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect". Journal of Medicinal Chemistry. 53 (23): 8274–86. doi:10.1021/jm101206p. PMC 3150605. PMID 21073191.
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