FGF13

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.[5][6]

FGF13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HBW, 4DCK, 4JPZ
Identifiers
Aliases	FGF13, FGF-13, FGF2, FHF-2, FHF2, fibroblast growth factor 13
External IDs	OMIM: 300070 MGI: 109178 HomoloGene: 3036 GeneCards: FGF13
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3-q27.1 Start 138,614,727 bp[1] End 139,222,777 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A6|X 33.31 cM Start 59,062,145 bp[2] End 59,568,071 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein kinase activator activity • GO:0001948 protein binding • growth factor activity • microtubule binding • sodium channel regulator activity • ion channel binding • beta-tubulin binding Cellular component • cell projection • filopodium • growth cone • extracellular region • dendrite • nucleolus • microtubules • cell nucleus • cytoplasm • cytosol • cell membrane • intercalated disc • lateral plasma membrane • axon • neuron projection Biological process • cell-cell signaling • nervous system development • MAPK cascade • signal transduction • neuron migration • activation of protein kinase activity • establishment of neuroblast polarity • negative regulation of collateral sprouting • sodium ion transport • negative regulation of microtubule depolymerization • learning • memory • hippocampus development • cerebral cortex cell migration • microtubule polymerization • protein localization to plasma membrane • regulation of cardiac muscle cell action potential involved in regulation of contraction • response to odorant • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2258	14168
Ensembl	ENSG00000129682	ENSMUSG00000031137
UniProt	Q92913	P70377
RefSeq (mRNA)	NM_001139498 NM_001139500 NM_001139501 NM_001139502 NM_004114 NM_033642	NM_001290414 NM_001290415 NM_010200 NM_001356335
RefSeq (protein)	NP_001132970 NP_001132972 NP_001132973 NP_001132974 NP_004105 NP_378668	NP_001277343 NP_001277344 NP_034330 NP_001343264
Location (UCSC)	Chr X: 138.61 – 139.22 Mb	Chr X: 59.06 – 59.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Börjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked intellectual disability, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.[6]