FGF6

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.[4][5]

FGF6
Identifiers
AliasesFGF6, HBGF-6, HST2, fibroblast growth factor 6
External IDsOMIM: 134921 MGI: 95520 HomoloGene: 10870 GeneCards: FGF6
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.32Start4,428,155 bp[1]
End4,445,614 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2251

14177

Ensembl

ENSG00000111241

ENSMUSG00000000183

UniProt

P10767

P21658

RefSeq (mRNA)

NM_020996

NM_010204

RefSeq (protein)

NP_066276

NP_034334

Location (UCSC)Chr 12: 4.43 – 4.45 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000111241 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM (Jun 2006). "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". J Biol Chem. 281 (23): 15694–700. doi:10.1074/jbc.M601252200. PMC 2080618. PMID 16597617.
  5. "Entrez Gene: FGF6 fibroblast growth factor 6".

Further reading



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