FGF3

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.[4]

FGF3
Identifiers
AliasesFGF3, HBGF-3, INT2, fibroblast growth factor 3
External IDsOMIM: 164950 MGI: 95517 HomoloGene: 3841 GeneCards: FGF3
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.3Start69,809,968 bp[1]
End69,819,416 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2248

14174

Ensembl

ENSG00000186895

ENSMUSG00000031074

UniProt

P11487

n/a

RefSeq (mRNA)

NM_005247

NM_008007

RefSeq (protein)

NP_005238

n/a

Location (UCSC)Chr 11: 69.81 – 69.82 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.[4]

Clinical significance

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.[4] Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.

Interactions

FGF3 (gene) has been shown to interact with EBNA1BP2.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000186895 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)".
  5. Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Aug 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226. PMID 11438656.

Further reading


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