LASSBio-881

LASSBio-881 is a drug which acts as both a non-selective partial agonist of the CB1 and CB2 cannabinoid receptors, and also as an antagonist of the TRPV1 receptor, as well as having antioxidant effects. It has potent anti-inflammatory and anti-hyperalgesic effects in animal studies.[1][2]

  • LASSBio-945 has an identical structure sans the nitro FG.
LASSBio-881
Identifiers
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC23H27N3O6
Molar mass441.484 g·mol−1
3D model (JSmol)

References

  1. Duarte CD, Tributino JL, Lacerda DI, Martins MV, Alexandre-Moreira MS, Dutra F, et al. (March 2007). "Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors". Bioorganic & Medicinal Chemistry. 15 (6): 2421–33. doi:10.1016/j.bmc.2007.01.013. PMID 17275312.
  2. Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, et al. (April 2010). "LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation". British Journal of Pharmacology. 159 (8): 1716–23. doi:10.1111/j.1476-5381.2010.00672.x. PMC 2925494. PMID 20401963.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.