MYH13

MYH13
Identifiers
Aliases	MYH13, MyHC-IIL, MyHC-eo, myosin, heavy chain 13, skeletal muscle, myosin heavy chain 13
External IDs	OMIM: 603487 MGI: 1339967 HomoloGene: 55780 GeneCards: MYH13
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	10,373,130 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	67,371,586 bp[2]
Gene ontology
Molecular function	• nucleotide binding; • actin binding; • microfilament motor activity; • cellular motor activity; • ATP binding; • calmodulin binding; • actin filament binding;
Cellular component	• cytoplasm; • myosin filament; • muscle myosin complex; • myofibril; • extracellular exosome; • myosin complex;
Biological process	• muscle contraction; • cellular response to starvation;
	Sources:Amigo / QuickGO
Orthologs
	8735
	544791
	ENSG00000006788
	ENSMUSG00000060180
	Q9UKX3
	n/a
	NM_003802
	NM_001081250
	NP_003793
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene.[5]

Function

MYH13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement.[6]

GRCh38: Ensembl release 89: ENSG00000006788 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000060180 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Winters LM, Briggs MM, Schachat F (November 1998). "The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17". Genomics. 54 (1): 188–9. doi:10.1006/geno.1998.5558. PMID 9806854.
Weiss A, Schiaffino S, Leinwand LA (July 1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.

Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
Schachat F, Briggs MM (2002). "Phylogenetic implications of the superfast myosin in extraocular muscles". J. Exp. Biol. 205 (Pt 15): 2189–201. PMID 12110653.
Trynka G, Zhernakova A, Romanos J, et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Schjeide BM, McQueen MB, Mullin K, et al. (2009). "Assessment of Alzheimer's disease case-control associations using family-based methods". Neurogenetics. 10 (1): 19–25. doi:10.1007/s10048-008-0151-3. PMC 2841132. PMID 18830724.
Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. PMC 1886840. PMID 8424456.

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