Keratin 34

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.[5][6][7][8]

KRT34
Identifiers
AliasesKRT34, HA4, Ha-4, KRTHA4, hHa4, Keratin 34
External IDsOMIM: 602763 MGI: 1309994 HomoloGene: 31083 GeneCards: KRT34
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.2Start41,377,650 bp[1]
End41,382,403 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3885

16672

Ensembl

ENSG00000131737
ENSG00000262045

ENSMUSG00000043485

UniProt

O76011

Q9D646

RefSeq (mRNA)

NM_021013

NM_027563

RefSeq (protein)

NP_066293

NP_081839

Location (UCSC)Chr 17: 41.38 – 41.38 MbChr 11: 100.04 – 100.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[8]

See also

References

  1. ENSG00000262045 GRCh38: Ensembl release 89: ENSG00000131737, ENSG00000262045 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000043485 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID 2431943.
  6. Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
  7. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  8. "Entrez Gene: KRT34 keratin 34".

Further reading


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