TNNC2

TNNC2
Identifiers
Aliases	TNNC2, troponin C2, fast skeletal type, CFAP85, FAP85
External IDs	OMIM: 191039 MGI: 98780 HomoloGene: 55727 GeneCards: TNNC2
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	45,833,745 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	164,779,967 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• actin binding; • GO:0001948 protein binding; • metal ion binding; • calcium-dependent protein binding; • actin filament binding; • calcium ion binding;
Cellular component	• cytosol; • troponin complex;
Biological process	• regulation of muscle contraction; • skeletal muscle contraction; • muscle filament sliding;
	Sources:Amigo / QuickGO
Orthologs
	7125
	21925
	ENSG00000101470
	ENSMUSG00000017300
	P02585
	P20801
	NM_003279
	NM_009394
	NP_003270
	NP_033420
	Wikidata
View/Edit Human	View/Edit Mouse

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.[5][6]

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.[6]

References

GRCh38: Ensembl release 89: ENSG00000101470 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000017300 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gahlmann R, Kedes L (Aug 1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene". J Biol Chem. 265 (21): 12520–8. PMID 2373703.
"Entrez Gene: TNNC2 troponin C type 2 (fast)".

Romero-Herrera AE, Castillo O, Lehmann H (1977). "Human skeletal muscle proteins. The primary structure of troponin C.". J. Mol. Evol. 8 (3): 251–70. doi:10.1007/bf01730999. PMID 978749. S2CID 12057790.
Tomasselli AG, Hui JO, Adams L, et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279.
Gahlmann R, Wade R, Gunning P, Kedes L (1988). "Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts". J. Mol. Biol. 201 (2): 379–91. doi:10.1016/0022-2836(88)90145-3. PMID 3166492.
Prentice H, Kloner RA, Prigozy T, et al. (1995). "Tissue restricted gene expression assayed by direct DNA injection into cardiac and skeletal muscle". J. Mol. Cell. Cardiol. 26 (10): 1393–401. doi:10.1006/jmcc.1994.1157. PMID 7869399.
Tiso N, Rampoldi L, Pallavicini A, et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast". Biochem. Biophys. Res. Commun. 230 (2): 347–50. doi:10.1006/bbrc.1996.5958. PMID 9016781.
Townsend PJ, Yacoub MH, Barton PJ (1998). "Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis". Ann. Hum. Genet. 61 (Pt 5): 457–9. doi:10.1046/j.1469-1809.1997.6150457.x. PMID 9459007. S2CID 1450195.
Vassylyev DG, Takeda S, Wakatsuki S, et al. (1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 4847–52. doi:10.1073/pnas.95.9.4847. PMC 20176. PMID 9560191.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101470 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017300 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2373703-5] Gahlmann R, Kedes L (Aug 1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene". J Biol Chem. 265 (21): 12520–8. PMID 2373703.

[entrez-6] "Entrez Gene: TNNC2 troponin C type 2 (fast)".

TNNC2

References

Further reading